张孝兵，协和特聘教授、博导。专注干细胞与基因治疗研究30年，发表论文百余篇，拥有中美发明专利20项、在审10余项。建立从CRISPRoff/on全基因组筛选到GMP载体生产的完整体系，发现多种可增强免疫治疗的新靶点。入选国家海外高层次领军人才，获天津市科技进步一等奖。团队倡导科研与人文并重，注重学生身心与学业的全面成长，评为优秀教师，鼓励国际交流，多名学生赴海外深造。
      院校引进人才，2022年加入院校，曾在罗马琳达大学任副教授。

研究iPSC向MSC、造血及神经系统定向分化，探索基因编辑与体内细胞治疗新策略。建立非整合重编程与高保真编辑体系，在血友病A和地中海贫血等基因治疗上取得突破；自主开发LNP/VLP体内递送平台，结合纳米抗体靶向，实现HSC与T细胞精准编辑；通过AI与多组学算法发掘治疗新靶点。更多成果见B站频道《基因画卷与细胞诗篇》：https://space.bilibili.com/3546556473019252。以国际化科研氛围和高效协作机制，鼓励学生从基础到转化、从实验到生信，成长为细胞基因治疗领域的未来领军人才。

亚洲通网址,亚洲通

1．Zhao JJ#, Tian SN#, Peng ZY#, Ren JX, Zhang YY, Li GH, Deng DH, Zhang JP*, Zhang XB*. Biomembrane-inspired lipid nanoparticles enhance CRISPR-Cas9 editing for hemophilia A. J Control Release. 2025 Aug 18:114141. (IF: 11.500)

2．Yang Z#, Fu Y, # Zhao J#, Zhang F, Li S, Zhao M, Wen W, Zhang L, Cheng T, Zhang J*, Zhang X*. Superior Fidelity and Distinct Editing Outcomes of SaCas9 Compared to SpCas9 in Genome Editing. Genomics Proteomics Bioinformatics. 2023 Dec;21(6):1206-1220. (IF: 9.500)

3．Quan ZJ#, Li SA#, Yang ZX, Zhao JJ, Li GH, Zhang F, Wen W*, Cheng T*, Zhang XB*. GREPore-seq: A robust workflow to detect changes after gene editing through long-range PCR and nanopore sequencing. Genomics Proteomics Bioinformatics. 2023 Dec;21(6):1221-1236. (IF: 9.500)

4．Pei YA#, Mikaeiliagah E#, Wang B, Zhang X*, Pei M*. The matrix microenvironment influences but does not dominate tissue-specific stem cell lineage differentiation. Mater Today Bio. 2023;23:100805. Published 2023 Sep 16. (IF: 8.680)

5．Wen W#, Quan ZJ#, Li SA#, Yang ZX, Fu YW, Zhang F, Li GH, Zhao M, Ying MD, Xu J, Zhang JP, Cheng T*, Zhang XB*. Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion. Genome biology. 2021 Aug 20;22(1):236. (IF: 17.906)

6．Fu YW#, Dai XY#, Wang WT#, Yang ZX, Zhao JJ, Zhang JP, Wen W, Zhang F, Kerby C. Oberg, Zhang L*,Cheng T*, Zhang XB*. Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ,MMEJ and HDR editing. Nucleic Acids Research, 2021 Jan 25;49(2):969-985. (IF: 19.160)

7．Wang Y#, Hu G#, Hill RC#, Dzieciatkowska M, Hansen KC, Zhang XB*, Yan Z*, Pei M*. Matrix reverses immortalization-mediated stem cell fate determination. Biomaterials. 2020 Sep 16;265:120387. (IF: 12.479)

8．Zhang JP#, Cheng XX#, Zhao M#, Li GH#, Xu J#, Zhang F, Yin MD, Meng FY, Dai XY, Fu YW, Yang ZX, Arakaki C, Su RJ, Wen W, Wang WT, Chen W, Choi H, Wang C, Gao G, Zhang L, Cheng T*, Zhang XB*. Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse. Genome Biology. 2019 Dec 16;20(1):276. (IF: 10.806)

9．Li XL#, Li GH#, Fu J#, Fu YW, Zhang L, Chen WQ, Arakaki C, Zhang JP, Wen W, Botimer GD, Baylink D, Aranda L, Choi H, Bechar R, Talbot P, Sun CK*, Cheng T*, Zhang XB*. Highly-efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by BCL-XL. Nucleic Acids Research, 2018 Nov 2;46(19):10195-10215. (IF: 11.147)

10．Zhang JP#, Li XL#, Li GH, Chen W, Arakaki C, Botimer GD, Baylink D, Zhang L, Wen W, Fu YW, Xu J, Chun N, Yuan W, Cheng T*, Zhang XB*. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated dsDNA cleavage. Genome Biology. 2017 Feb 20;18(1):35. (IF: 13.214，C100)